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Discover the Effect of Compounds on

Receptors Like GPCRs

Using MULTISCREEN™ HTS Internalization Assay

 

• Simple: Live-cell flow cytometry (FACS)

 

• High-throughput: Assay in 96-well format

 

• Comprehensive: Kinetic and dose-dependent ligand responses

 

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MULTISCREENTM MOR Internalization Assay

April 2024 Eblast Data.3
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GPCR Internalization

 

β-arrestin recruitment promotes receptor internalization

via clathrin-coated pits;

Some GPCRs are internalized via arrestin-independent mechanisms

Internalization figure
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What do our customers say?

"Multispan performs GPCR screening for us on a battery of 32 typical targets and off-target GPCRs in drug discovery. What is most impressive about their work product is that they determine functionality (agonist, partial agonist and antagonist) and potency from dose-response curves using multiplexing of assays. After comparison between vendors, we found Multispan to be the least expensive option and to provide the greatest value for the funds we have available. The post-assay customer interface is excellent in that they answer questions and provide relevant commentary as needed."
 
Allen Reitz, Ph.D.
Chief Executive Officer, Fox Chase Therapeutics Discovery, Inc.

 

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info@multispaninc.com

 

www.multispaninc.com

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Multispan, Inc., 26219 Eden Landing Road, Hayward, CA 94545, United States, 510-887-0817

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