MULTISCREEN™ β-Arrestin Assay Solutions for Native GPCRs

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Don't Let GPCR Tagging Bias Your Results!

• Study untagged GPCR in all assays in ONE single cell line,

enabled by MULTISCREEN™ β-Arrestin technology

• Save valuable time and reduce cost

by eliminating using different cell lines for different assays

• 560+ Validated MULTISCREEN™ GPCR stable cell lines

readily transduced by MULTISCREEN™ β-Arrestin viral particles

• Available as custom cell lines and assay kits

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MULTISCREEN™ GPCR β-Arrestin Assay Examples

HEK293T AT1 Stable Cell Line Transiently Transduced

with β-Arrestin1 and β-Arrestin2 BacMam Sensors

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Multispan Champions in Vitro Biology Screening

from Target to IND

Saving >12 Months of Assay Development and Transfer

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What Do Our Customers Say?

“Over the past two years I worked with Multispan on the discovery and optimization of partial agonist ligands for a Gi/o coupled GPCR. Multispan supported the in vitro effort that enabled the compound optimization by implementing and running radiolabel binding assays to evaluate the affinity of ligands, cAMP assays in agonist and antagonist modes to evaluate functional activity, GTPgS assays to accurately measure the efficacy of ligands on the receptor, ARRB-2 assays to evaluate the arresting signaling pathway and receptor internalization assays to evaluate functional activity. The work performed by Multispan was professional with good reproducibility from week-to-week, quick turnaround and cost effective. The Multispan team is easy to work with and when the assays deviated from the norm they were quick to repeat the data and address problems."

Julio Medina, Ph.D.

R2M Pharma Inc.

C.E.O.

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info@multispaninc.com

www.multispaninc.com