MULTISCREEN™ HTS β-Arrestin Assay for Native GPCRs

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Pioneering Next-Gen GPCR Assays

○ TRUE PHARMACOLOGY

Enables the study of untagged GPCRs in their native form

to mirror true physiological interactions

○ RELEVANCE IN DATA

Allows for the assay of endogenously expressed GPCRs

to reflect in-vivo conditions

○ MAXIMUM VERSATILITY

Characterizes orphan GPCRs with “All-Assays-in-One-Cell-Line”

broadening potential targets and streamlining drug development

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MULTISCREEN™ GPCR β-Arrestin Assay Examples

HEK293T AT1 Stable Cell Line Transiently Converted

with β-Arrestin1 and β-Arrestin2 BacMam Sensors

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MULTISCREEN™ HTS β-Arrestin Assay Technology

for Native GPCRs in Recombinant or Primary Cells

Unique Membrane Sensor Eliminated GPCR Tagging

Beta_Arrestin_Assay_Technology_Principle-768x1172 v2

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What Do Our Customers Say?

“Over the past two years I worked with Multispan on the discovery and optimization of partial agonist ligands for a Gi/o coupled GPCR. Multispan supported the in vitro effort that enabled the compound optimization by implementing and running radiolabel binding assays to evaluate the affinity of ligands, cAMP assays in agonist and antagonist modes to evaluate functional activity, GTPgS assays to accurately measure the efficacy of ligands on the receptor, ARRB-2 assays to evaluate the arresting signaling pathway and receptor internalization assays to evaluate functional activity. The work performed by Multispan was professional with good reproducibility from week-to-week, quick turnaround and cost effective. The Multispan team is easy to work with and when the assays deviated from the norm they were quick to repeat the data and address problems."

Julio Medina, Ph.D.

R2M Pharma Inc. C.E.O.

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info@multispaninc.com

www.multispaninc.com