"Multispan provided us with target engagement data for a novel target for a rare genetic neurological disease. I collaborated with scientists at Multispan to optimize the conditions for a Gi/o coupled GPCR to generate robust assay data for both AI-generated focused library screening and dose-response potency data. In conjunction with our in-house brain organoid disease model data, we successfully identified candidates for lead optimization that engage the target and rescue the disease phenotype. Multispan scientists were proactive to suggest approaches to optimize assay quality and conducted additional experiments on several occasions to ensure high assay quality."
---Jon Hawkinson, Ph.D.
Former Vice President, Drug Discovery, Vyant Bio Adjunct Professor, Department of Medicinal Chemistry, University of Minnesota